Ruben Savizky
Associate Professor of Chemistry
Ph.D., Chemistry 2005
Yale University
Research Advisors: Prof. David J. Austin and Prof. Donald M. Crothers
Dissertation: “Synthetic and Biophysical Efforts Toward an Understanding of RNA Structure”
M.S., Chemistry 2000
Yale University
B.E., Chemical Engineering 1998
The Cooper Union
Summa Cum Laude Graduate
Education:
Ph.D., Chemistry 2005
Yale University
Research Advisors: Prof. David J. Austin and Prof. Donald M. Crothers
Dissertation: “Synthetic and Biophysical Efforts Toward an Understanding of RNA Structure”
M.S., Chemistry 2000
Yale University
B.E., Chemical Engineering 1998
The Cooper Union
Summa Cum Laude Graduate
Professional Experience:
The Cooper Union for the Advancement of Science and Art
Associate professor of chemistry:
teaching courses in general chemistry, physical chemistry, organic chemistry, analytical chemistry and biochemistry.
2011-pressent
Assistant professor of chemistry:
teaching courses in general chemistry, physical chemistry, organic chemistry, analytical chemistry and biochemistry.
2005-2011
Adjunct professor in the chemistry department, teaching courses in physical chemistry and organic chemistry.
2005
Columbia University
Adjunct professor, teaching courses in general chemistry and organic chemistry.
2009-present
New York University
Adjunct professor, teaching a summer course in organic chemistry.
2008
Polytechnic Institute of NYU
Adjunct professor, teaching courses in biochemistry.
2008-present
The Mt. Sinai School of Medicine
Adjunct professor, teaching a summer course in organic chemistry for incoming medical students.
2007-present
Yale University
The design of small molecules to specifically target and recognize RNA molecules, particularly those involved in RNA/protein interactions critical for HIV replication. Conducted under the guidance of Prof. David J. Austin and Prof. Donald M. Crothers.
1999-2004
Publications:
- Katlowitz, K., Weinberg, J. and Savizky, R. M. “Theoretical and Experimental Investigations of RNA Unfolding Thermodynamics” (manuscript in preparation)
- Suh, J. and Savizky, R. M. “Metal Ion Binding Effects on the Thermodynamic Stability of Human alpha-Lactalbumin: Intrinsic Fluorescence Studies” (manuscript in preparation)
- Leung, W. W. and Savizky, R. M. “Kinetic Analysis of Chalcone Epoxidation in a Biphasic System”, Ind. Eng. Chem. Res., 49 (2010), 12327-30
- Savizky, R. M. and Austin, D. J. “Rhodium(II) Catalyzed 1,3-Dipolar Cycloadditions” in Modern Rhodium-Catalyzed Organic Reactions, Evans, P. A. Ed., Wiley Interscience, Cambridge, 2005
- Lee, Y., Yeo, H., Liu, S.H., Jiang, Z., Savizky, R. M. and Austin, D. J. “Increased Anti-P-glycoprotein Activity of Baicalein by Alkylation on the A Ring”, J. Med. Chem., 47 (2004), 5555-66
- Savizky, R. M., Suzuki, N. and Bové, J. L.”The use of sonochemistry in the asymmetric epoxidation of substituted chalcones with sodium perborate tetrahydrate”, Tetrahedron:Asymmetry, 9 (1998), 3967-9
Master’s Theses:
- Ji Suk (James) Suh, “Metal Ion Binding Effects on the Thermodynamic Stability of Human alpha-Lactalbumin: Intrinsic Fluorescence Studies”, May 2010
- Doo Won Kim, “Effect of Cationic Surfactant (N-Alkyl Trimethylammonium Bromide, CnTAB) Hydrophobicity on Cellulase Intrinsic Fluorescence”, May 2010
- Wai Wing Leung, “Kinetic Analysis of Chalcone Epoxidation in a Biphasic System”, May 2010
- Chonghag Kim, “Fluorescence Quenching Study of the Human Serum Albumin-Quercetin Complex by Cu(II), Ni(II) and Mn(II) Addition”, May 2011
- Brielle Eisen, “A Chemical Investigation of Ancient Art Using Modern Analytical Techniques: Characterization of Roman Wall Paintings”, May 2011
Reviews:
- Datta, S., Bucks, M. E., Koley, D., Lim, P. X. and Savinov, S. N., “Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system”, Bioorg. Med. Chem., 2010
- McMurry, J. and Fay, R. C., Chemistry, 5th. Ed., Pearson Hall, 2007
- Goldhaber-Gordon, I. and Solomon, D., Thinking Like a Biochemist, University Science Books, 2006 (unpublished manuscript)
Presentations:
- Organizer, New York American Chemical Society Younger Chemists Committee Research Symposium, The Cooper Union, 2011
- Invited Speaker, CUNY Careers for Chemists Symposium, City University of New York, 2010
- Organizer, Encaustic Art Symposium, The Cooper Union, 2010
- Invited Speaker, Chocolatefest Part II, Science House (New York), 2010
- Organizer, Chocolatefest, The Cooper Union, 2010
- Invited Speaker, New York American Chemical Society Younger Chemists Committee Career Panel, Columbia University, 2010
- Poster presentation (x2), End of Year Show, The Cooper Union, 2010
- Organizer, “Architecture in Nanospace”, a presentation by Sir Harold Kroto, Polytechnic Institute of NYU, 2010
- Poster presentation at Pittcon, Orlando, 2010
- Invited Speaker, AIChE Alumni Night, The Cooper Union, 2010
- Invited Speaker, AIChE Alumni Night, The Cooper Union, 2009
- Oral presentation at 47th Eastern Analytical Symposium, Somerset, 2007
- Poster presentation at 232th American Chemical Society National Meeting, San Francisco, 2006
- Poster presentation at 47th Annual Experimental NMR Conference, Asilomar, 2006
- Poster presentation at 6th Annual Bristol-Myers-Squibb (BMS) Symposium, Yale University, 2003
- Poster presentation at 226th American Chemical Society National Meeting, New York City, 2003
- Poster presentation at 6th Annual Chemical Biology Symposium, Yale University, 2003
- Poster presentation at Greater Metropolitan Area 2003 Chemistry Graduate Student Poster Session, New York University, 2003
- Oral presentation at 224th American Chemical Society National Meeting, Boston, 2002
- Oral presentation at 5th Annual Bristol-Myers-Squibb (BMS) Symposium, Yale University, 2002
- Poster presentation at 4th Annual Chemical Biology Symposium, Yale University, 2003
- Alumni Speaker, The Cooper Union, 2001
- Poster presentation at Northeast Regional Meeting of the American Chemical Society, University of Connecticut, Storrs, CT, 2000
- Oral presentation at NYC American Chemical Society 46th Annual Undergraduate Research Symposium, New York University, 1998
Professional Memberships and Service:
- American Chemical Society, 1995-present
- Member of Board of Directors for Brooklyn Sub-section, 2009-present
helped organize events throughout New York City, such as our annual Brooklyn Frontiers lecture, which was attended by over 100 high school students, undergraduates, graduate students, post-doctoral fellows, professors, industry and government employees throughout the New York City area. - Member of Younger Chemists Committee, 2009-present
helped organize events throughout New York City, such as our inaugural Research Symposium, which was attended by almost 100 high school students, undergraduates, graduate students, post-doctoral fellows, professors, industry and government employees throughout the New York City area.
- Member of Board of Directors for Brooklyn Sub-section, 2009-present
- American Institute of Chemical Engineers, 1994-1998
- Served as President of Cooper Union Student Chapter, 1996-1997
- Served as Vice-President of Cooper Union Student Chapter, 1995-1996
- Biophysical Society, 2001-2004
- National Society of Professional Engineers, 1994-1998
- Society of Hispanic Professional Engineers, 1994-1998
- Served as Treasurer of Cooper Union Student Chapter, 1996-1998
- Tau Beta Pi (Engineering Honor Society), 1997-present
- Yale University Biotechnology Special Interest Group, 2002-2005
Languages:
- Fluent in Spanish and English
Laboratory:
- Microscale to macroscale multi-step organic synthesis. Extensive use of rhodium-catalyzed cycloaddition reactions. Experience with small scale combinatorial chemistry and solid-phase techniques, including peptide synthesis.
- Organic reaction optimization, including variable temperature and inert atmosphere manipulations.
- Purification techniques such as distillation, flash chromatography, TLC, and HPLC
- Purification and analysis of nucleic acids using PAGE with 32P labeled nucleotides
- Experience with molecular biology protocols such as PCR, growing E. coli and working with T7 bacteriophage
- Analysis techniques such as 1H and 13C NMR, , multidimensional NMR, IR, LC-MS, GC-MS, FRET and fluorescence polarization
Computers:
- Literature searching using SciFinder Scholar, Beilstein Crossfire, ISI Web Of Knowledge and ChemFinder
- Chemistry and modeling software including ChemDraw, ISIS/Draw, Chem3D, BOSS, Spartan, Rasmol and Dragon
- General programs such as MS Word, Excel, PowerPoint, Outlook, Adobe Acrobat, Reader, Photoshop and EndNote
Awards received:
- Student’s List Award, The Cooper Union, 2009
- Benjamin Menschel Fellowship, The Cooper Union, 2009
- Student’s List Award, The Cooper Union, 2008
- Henry Bradford Loomis Fellowship, Yale University, 2002
- Lars Onsager Fellowship, Yale University, 1998-2002
- NIH Biophysical Chemistry Training Grant, 1998 and 2000
- Honorable Mention in NSF Minority Graduate Fellowship Competition, 1998
- Full-Tuition Scholarship to The Cooper Union, 1994-1998
- National Dean’s List, 1994-1998
- 2nd Place in AIChE Regional Student Paper Competition, 1998
- Lewis Gleekman Memorial Prize for Materials Science/Engineering, 1998
- United Federation of Teachers Scholarship, 1994-1998
- Robert C. Byrd Honors Scholarship, 1994-1998
- Society of Hispanic Professional Engineers Scholarship, 1994-1998
- National Hispanic Scholarship Fund Scholarship, 1994 and 1996-1998
- National Society of Professional Engineers Scholarship, 1994
