David M. Wootton
Associate Professor of Mechanical Engineering
Dr. Wootton teaches fundamental courses in mechanics and mechanical engineering (fluid and solid mechanics, engineering mechanics/dynamics), and bioengineering electives (Biotransport, Injury Biomechanics and Safety, Tissue Engineering). He has advised a variety projects for seniors, freshmen, master’s degree, and independent studies, including: exercise equipment for overweight teens; experimental systems for impact injury, bone interference screw strength, knee mechanics, and upper airway mechanics; folding bicycle design; microchannel blood platelet inhibition assay; bone and osteochondral tissue engineering scaffold manufacturing; bone interference screw testing, and atomic force microscopy.
Dr. Wootton’s main research interests are biofluid and biosolid mechanics and biotransport modeling, Current research projects in this area include magnetic resonance image-based upper airway fluid and solid mechanics models to better understand anatomic and neuromuscular factors contributing to obstructive sleep apnea syndrome, and novel (often CAD/CAM based) manufacturing methods for tissue engineering scaffolds and constructs. His past studies in this area include models of flow, near-wall platelet concentration, and platelet accumulation in arterial thrombosis, which linked the flow field features typically found in advanced atherosclerosis (artery disease) with the enhanced rate of blood clot formation (thrombosis) associated with many heart attacks and strokes. He also developed an experimental and computational model of thrombolytic (“clot-busting”) drug therapy in remnants of thrombus adhering to a vessel wall after blood flow is reestablished. His research is currently supported by federal grants from the National Institutes of Health and National Science Foundation, and he has been supported by the American Heart Association. Dr. Wootton is also interested in introducing novel experiments and demonstrations in the engineering curriculum, and participates in an NSF-sponsored project to bring microfluidics experiments into the introductory courses in fluid mechanics and Biotransport. He is collaborating with Professor Delegrammatikas and Cooper Alum and ME lab manager John Consiglio to introduce particle image velocimetry (PIV) to undergraduate student courses and projects (funded by NSF).
Dr. Wootton studied Mechanical Engineering Cornell University (BS 1987), MIT (MS 1990), and Georgia Tech (PhD 1998), and Biomedical Engineering at Georgia Tech (PhD subject area) and Johns Hopkins University (Postdoc 1998-2000). His professional experience includes Crashworthiness and Safety Engineering at General Motors, environmental noise and vibration (Harris Miller Miller and Hanson), and musical instrument repair and restoration (Reuning and Son Violins).
PhD, Mechanical Engineering, 1998
Georgia Institute of Technology, Atlanta, GA
MS, Mechanical Engineering, 1990
Massachusetts Inst. of Technology, Cambridge, MA
BS, Mechanical Engineering, 1987
Cornell University, Ithaca, NY
Cooper Union for the Advancement of Science and Art, New York, NY
Associate Professor of Mechanical Engineering,
Sept 2006 – Present
Director, Kanbar Center for Biomedical Engineering
Jan 2007 - Present
Drexel University, Philadelphia, PA
Sept 2000 – Aug 2006
Johns Hopkins University, Baltimore, MD
Oct 1998 – Sept 2000
General Motors Corporation, Warren, MI
Project Engineer, Safety and Crashworthiness Systems
Sept 1990- Mar 1994
Harris Miller Miller and Hanson Inc, Burlington, MA
Environmental noise and vibrations consultant
Feb 1987 – Aug 1987
Mechanochemical and dynamic models of thrombosis and thrombolysis
Novel biosensor designs for blood hemostatic research, diagnosis, and monitoring
The role of fluid mechanics and biological processes in cell transport
Measurement of blood cell concentration and motion under arterial flow conditions
Upper airway fluid and solid mechanics in obstructive sleep apnea
Computational Fluid Dynamics Lab including a Compaq Alpha XP1000 professional workstation, and industry standard computational fluid mechanics software.
Experimental/Teaching Cell and Tissue Engineering Lab facility.
In vitro models of blood, blood analog, and airway flow.
Honors and Awards
National Science Foundation Graduate Fellow, M. I. T., 1987-1988
President’s Fellowship, Georgia Tech, 1994–1998
Whitaker Foundation Trainee, Georgia Tech, 1994-1998
Best Mechanical Engineering Ph. D. Qualifying Exam, Georgia Tech, Spring 1995
BellSouth Scholar, A. R. C. S. Atlanta, 1996–1998
Distinguished Postdoctoral Fellowship, Johns Hopkins, 1998 – 2000
Undergraduate Teaching Award, Dept. of Mechanical Engineering and Mechanics, Drexel University, 2002-2003
Member, Biomedical Engineering Society
Member, American Society of Mechanical Engineers - Biofluid Mechanics Technical Committee
Session Organizer and Chair, Thrombosis and Cellular Fluid Mechanics, BED6B, IMECE 2002.
Session Organizer and Chair, Cardiovascular Fluid Mechanics Bypass and Access Grafts, BED2B, IMECE 2003.
Program Committee and Session Chair, NorthEast Bioengineering Conference, Springfield, MA, April 17-18, 2004.
Session Organizer and Chair, Thrombosis and Rheology, BMES 2005 Annual Fall Meeting, Baltimore, MD, Sept 29 – Oct 1, 2005.
Annals of Biomedical Engineering
Encyclopedia of Medical Devices and Instrumentation (Wiley)
Journal of Biomechanical Engineering
Journal of Biomechanics
Medical Research Council (Britain)
National Science Foundation (Bioengineering Program)
Prentice-Hall (Fluid Mechanics in the Human Circulation, a new textbook)
Mechanical Engineering Transition Committee, 2007- present
Interdisciplinary Engineering Oversight Committee, 2008-present
Ad hoc Campus Safety Committee, 2009-present
Ad hoc Institutional Human Subjects Research Committee, 2009-present
Dean’s Advisory Committee, 2003
Undergraduate Affairs Committee, 2000 –2002
MEM Department Head Search Committee, 2001
- Holland and Knight Building Bridges, Atlanta, GA. 1997-1998. Introducing law and engineering to young students through participation in a mock trial.
- Drexel COE Summer Mentorship, July 2002. Two week summer research experience for high school junior. Mentoring high school sophomore honors student interested in medicine and engineering.
- Research Experiences for Teachers (RET), Drexel University, 2003.
- Exercise Equipment for B’N FIT, Cooper Union and the Children’s Hospital at Montefiore, 2008 – present. Freshmen design students (EID101) have designed a series of low-cost exercise systems for overweight teens in the B’N FIT program; each with some unique incentive. Systems include exercise bikes that drive adventure chase and competitive race video games, a stepper that controls current to an entertainment device, and an 8-pad foot operated device for playing synthesized drums or music. Students have talked about engineering and design to children in the clinic.
- Biofluid Mechanics (Graduate/Undergraduate), Drexel University, 2001-2006. (MEM 444)
- Crash Data Filtering (Short Course), General Motors Corporation, Fall 1993.
- CFD modules for undergraduate and graduate fluid mechanics courses.
- Bioengineering in Safety, Design and Injury Analysis and Prevention, Cooper Union EID124
- Introduction to Tissue Engineering, Cooper Union, EID323/ME323, Spring 2007
- Mechanics of Materials, Cooper Union, ESC101M, Spring 2008 - 2009
- Fluid Mechanics, Cooper Union, ESC140M, Fall 2006 - 2009
- Engineering Design and Problem Solving, Cooper Union, EID101, Fall 2006 – 2009
- Biotransport Phenomena, Cooper Union, EID121, Spring 2009
- Bioengineering in Safety, Design and Injury Analysis and Prevention, Cooper Union EID124, Spring 2008
- Foundations of Fluid Mechanics (Grad), Drexel University, MEM 621, 2000-2005
- Boundary Layers, Laminar and Turbulent (Grad), Drexel University, MEM 622, 2001-2006
- Heat Transfer (Undergrad), Drexel University, MEM 345, 2006
- Dynamics (Undergrad), Drexel University, MEM 238, 2005 - 2006
- Fluid Dynamics I (Undergrad), Drexel University, MEM 320, 2002
- Dynamics Laboratory, Cornell University.
- Intermediate Dynamics, Massachusetts Institute of Technology.
- Fluid Mechanics III, Georgia Institute of Technology.
- Thermodynamics I, Georgia Institute of Technology.
- Cardiovascular Physiology Simulation Lab, Johns Hopkins University School of Medicine.
- Coadvisor for Sangho Kim (MEM) PhD 2002 Assistant Professor, U. of Singapore
- Chun Xu (MEM) PhD 2006 Postdoc, U. of Pennsylvania
- Chang-Beom Kim (MEM) PhD 2006 Postdoc, Drexel University
- Chun Xu (MEM) MS 2003
- Brad Xanthopolous (Independent study)
- Priya Vaidyanathan (Biomed) MS 2004
- Sanghun Sin (Biomed) MS 2004
- Matthew Appel (MEM) MS 2006
- Sharon Markowitz (ME) MS 2008
- Hyun Soo Ko (ME) MS 2009
- Stephen Persak (ME) MS 2010
- Neal Kinariwala (ME)
- Yeji Kim (ME)
- Jonathan Sterman (ME)
- Joshua Warren (ME)
- Brian Schmidt (MEM) BS 200
- Kirk Edwards (MEM) BS 2003
- Vince Yanni (MEM) BS 2004
- Bryan Bowker (MEM) BS 2005
- John (Jack) Kuhar (MEM) BS 2006
- Brian Tovar (ME) BS 2008
- Christopher Phaneuf (ME) BS 2008
- May Chang (ME) BS 2008
- Andrea Zaferiou (ME) BS 2010
- Helen Minsky (ME) BS 2011
Publications and Presentations:
- Wootton DM, Ku DN, “Fluid Mechanics of Vascular Systems, Diseases, and Thrombosis,” Annual Review of Biomedical Engineering, V. 1, pp. 299-329, 1999. [abstract]
- Jerius H, Karolyi DR, Mondy JS, Beall A, Wootton D, Ku D, Cable S, Brophy CM, “Endothelial-dependent vasodilation is associated with increases in the phosphorylation of a small heat shock protein (HSP20)”, Journal of Vascular Surgery, V. 29, pp. 678-84, 1999.
- Wootton DM, Markou CP, Hanson SR, Ku DN, “A Mechanistic Model of Acute Platelet Accumulation in Thrombogenic Stenoses,” Annals of Biomedical Engineering, V. 29, pp. 321-329, 2001. [abstract]
- Wootton DM, Popel AS, Alevriadou BR, “An Experimental and Theoretical Study on the Dissolution of Mural Fibrin Clots by Tissue-Type Plasminogen Activator,” Biotechnology and Bioengineering, V. 77, #4, pp. 405-419, 2002. [abstract]
- Xu C, Wootton DM, “Platelet Near-Wall Excess in Porcine Whole Blood in Artery-Sized Tubes Under Steady and Pulsatile Flow Conditions”, Biorheology, V. 41, pp 113-125, 2004. [abstract]
- Arens R, Sin S, McDonough JM, Palmer J, Dominguez T, Meyer H, Wootton DM, Pack AI, “Changes in Upper Airway Size during Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome,” Am. Journal of Respiratory and Critical Care, V. 171, #11, pp. 1292-1297. 2005. [abstract]
- Xu C, Sin S, McDonough M, Udupa JK, Arens R, Guez A, Wootton DM, “Computational Fluid Dynamics Modeling of the Upper Airway of Children with Obstructive Sleep Apnea Syndrome in Steady Flow,” Journal of Biomechanics, V. 39, #11, pp. 2043-2054, 2006. [abstract]
- Mondrinos M, Dembzymsky R, Lu L, Byrapogu, VKC, Wootton DM, Lelkes PI, Zhou GJ, “A Porogen-based Solid Freeform Fabrication of Polycaprolactone-Calcium Phosphate Scaffolds for Tissue Engineering,” Biomaterials, V. 27, #25, pp. 4399-4408, 2006. [abstract]
- Ergezen E, Appel M, Shah P, Kresh JY, Lec RM, Wootton DM, “Real-Time Monitoring of Adhesion and Aggregation of Platelets using Thickness Shear Mode (TSM) Sensor,” Biosensors and Bioelectronics, V. 23, #4, pp. 575-82, 2007. [abstract]
- Zhou J, Lu L, Byrapogu K, Wootton DM, Lelkes PI, Fair R, “Electrowetting-based multi-microfluidics array printing of high resolution tissue construct with embedded cells and growth factors,” Virtual and Physical Prototyping, V. 2, #4, pp. 217-223, 2007. [abstract]
- Marcus C, Smith RJH, Mankarious L, Arens R, Mitchell G, Elluru RG, Forte V, Goudy S, Jabs EW, Katz E, Paydarfar D, Reeves RH, Richtsmeier JT, Ruiz RL, Thach BT, Tunkel DE, Whitsett JA, Wootton D, Blaisdell CJ, “Developmental Aspects of the Upper Airway, Report from an NHLBI Workshop March 5-6, 2009.” Proceedings of the American Thoracic Society, V. 6, #6, pp. 513-520, 2009. [abstract]
- Xu C, Brennick MJ, Dougherty L, Wootton DM, “Modeling of Upper Airway Collapse by Regional Tissue Properties in a Finite Element Model,” Medical Engineering and Physics, V. 31, #10, pp. 1343-1348, 2009. [abstract]
- Lu, Lin, Zhang, Qingwei, Wootton, David, Lelkes, Peter, and Zhou, Jack, “A novel sucrose porogen-based solid freeform fabrication system for bone scaffold manufacturing,” Rapid Prototyping Journal, V. 16, #5, pp. 365-376, 2010. [abstract]
- Arens R, Sin S, Nandalike K, Rieder J, Khan U, Freeman K, Wylie-Rosett J, Lipton M, Wootton DM, McDonough JM, Shifteh K. “Upper Airway Structure and Body Fat Composition in Obese Children With Obstructive Sleep Apnea Syndrome,” American Journal of Respiratory and Critical Care, 2011 Mar 15;183(6):782-7. [abstract]
- Arens R, Sin S, Willen S, Bent J, Parikh SR, Freeman K, Wootton DM, McDonough JM, Shifteh K. “Rhino-sinus involvement in children with obstructive sleep apnea syndrome,” Pediatric Pulmonology. 2010 Oct;45(10):993-8. [abstract]
- Persak SC, Sin S, McDonough JM, Arens R, Wootton DM. “Noninvasive estimation of pharyngeal airway resistance and compliance in children based on volume-gated dynamic MRI and Computational Fluid Dynamics,” Journal of Applied Physiology. Accepted 2011 Aug 18. [abstract]
- Bergman HL, Chesler N, Ku DN, Wootton DM, "Hemodynamics and Atherosclerosis," Ch. 9 of Cerebrovascular Ultrasound, Hennerici MC, Meairs S, editors, Cambridge University Press, 2001.
Conference Articles and Presentations
Wootton DM, Hanson SR, Markou CP, Ku DN, “Mass Transfer Modeling of Arterial Thrombosis in Ex Vivo Thrombosis Models,” Annals of Biomedical Engineering, V. 25 (S1), p. S-2, 1997.
Wootton DM, Markou CP, Hanson SR, Ku DN, “Mechanistic Model of Arterial Thrombosis in Collagen-Coated Stenoses,” Advances in Bioengineering, V. 39, pp. 115-6, ASME-BED, 1998.
Wootton DM, Popel AS, Alevriadou BR, “A Model of Lysis of Mural Platelet-Fibrin Thrombi,” BMES-EMBS First Joint Meeting, Oct 13 -15,1999, Atlanta, GA, Abstract 22.214.171.124, p. A133.
Wootton DM, Markou CP, Hanson SR, Ku DN, “Effect of Activation Kinetics on Platelet Accumulation in a Thrombogenic Stenosis,” BMES Fall Annual Meeting, Oct 4-7, 2001, Durham, NC, Abstract 5.9.6.
Lamkin-Kennard K, Buerk DG, Barbee K, Wootton D, Jaron D, “Modeling Effects of Nitric Oxide on Oxygen Consumption in the Microcirculation,” Proceedings of the IEEE 28th Annual Northeast Bioengineering Conference, Apr 20-21, 2002, Philadelphia, PA, pp 31-32.
Xu C, Wootton DM, “A model of platelet concentration sampling in arterial flow,” Paper # 981, Second joint meeting of EMBS and BMES, October 23-26, 2002, Houston, TX.
Wootton DM, “A Continuum Model of Thrombus Growth and Flow Impingement,” Paper # IMECE2002-32786, ASME IMECE, November 17-22, 2002, New Orleans, LA.
Wootton DM, Guez A, Vaidyanathan P, Avinash D, Stablum JR, McDonough JM, Udupa JK, Arens R, “Model of Upper Airway Flow Restriction in Children with Obstructive Sleep Apnea,” Paper #126.96.36.199, Proceedings of the IEEE 29th Annual Northeast Bioengineering Conference, Newark, NJ, March 22-23, 2003.
Wootton DM, Guez A, Vaidyanathan P, McDonough JM, Udupa JK, Arens R, “Image-based Modeling of Upper Airway Resistance in Children with Obstructive Sleep Apnea Syndrome”, Associated Professional Sleep Societies 17th Annual Meeting, Chicago IL, June 3-8, 2003. Abstract published in Sleep 26(suppl): A233
Wootton DM, Guez A, Vaidyanathan P, McDonough JM, Udupa JK, Arens R, “Image-based Modeling of Upper Airway Flow in Children with Obstructive Sleep Apnea”, Paper #0779,, 2003 Summer Bioengineering Meeting (ASME/BMES), Key Biscayne, June 23 – 29, 2003.
Schmidt BR, Kim CB, Mohamed F, Nunes LW, Ahmed Z, Wootton DM, “Image-based Modeling of Arteriovenous Hemodialysis Access Graft Flow”, Paper #IMECE2003-42952, ASME IMECE, November 15-21, 2003, Washington, DC.
Burns MP, Jones CI, Wootton DM, Alevriadou RB, “Design of a Flow System for Exposure of Cultured Vascular Endothelial Cells to Ischemia/Reperfusion,” FASEB Experimental Biology 2004, Washington, DC, April 17-21, 2004
Kim CB, Kresh JY, Wootton DM, “A Novel Translating-Stage Assay to Study Platelet Concentration, Transport, and Adhesion Kinetics,” paper 125226, BMES 2004 Annual Fall Meeting, Philadelphia, PA, October 2004.
Xu C, Guez A, McDonough JM, Arens R, Wootton DM, “Finite Element Model Of Air Flow In A Stenotic Channel With Large Wall Deformation And Collapse,” paper 125164, BMES 2004 Annual Fall Meeting, Philadelphia, PA, October 2004.
Vaidyanathan P, Guez A, Udupa JK, Arens R, Wootton DM, “Automated System for Image-Based Upper Airway Flow Modeling,” paper 125218, BMES 2004 Annual Fall Meeting, Philadelphia, PA, October 2004.
Sin S, Wootton DM, Guez A, Pierson R, Schwab R, McDonough JM, Arens R, “Computational Modeling of Upper Airway Flow using MR Image of Adult with Obstructive Sleep Apnea,” paper 125278, BMES 2004 Annual Fall Meeting, Philadelphia, PA, October 2004.
Mondrinos M, Lu L, Dembzynski R, Wootton DM, Lelkes PI, Zhou GJ, “Solid Free Form Fabrication System for Manufacturing of Scaffold Porogens,” paper 123437, BMES 2004 Annual Fall Meeting, Philadelphia, PA, October 2004.
Xu C, Brennick M, Wootton DM, “Image-based three-dimensional finite element modeling approach for upper airway mechanics,” 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS), Sept.1-4, Shanghai, China, 2005.
Xu C, Brennick M, Wootton DM, “Pharyngeal Airway Collapse Modeling by Magnetic Resonance Imaging with Computational Mechanics,” BMES 2005 Annual Fall Meeting, Baltimore, MD, September 2005.
Wootton DM, Xu C, Sin S, McDonough J, Guez A, Arens R, “Computational Fluid Dynamics Model of Airway Shape Effects in Children with Obstructive Sleep Apnea,” BMES 2005 Annual Fall Meeting, Baltimore, MD, September 2005.
Kim CB, Kresh JY, Wootton DM, “A Novel Translating-Stage Assay to Study Platelet Concentration, Transport, and Adhesion Kinetics”, BMES 2005 Annual Fall Meeting, Baltimore, MD, September 2005.
Lu L, Dembzynski R, Mondrinos M, Wootton DM, Lelkes PI, Zhou GJ, “Manufacturing System Development for Fabrication of Bone Scaffold,” Paper # IMECE2005-80937, ASME International Mechanical Engineering Conference and Exposition, Orlando, FL, November 2005 (peer-reviewed conference paper).
Wootton DM, Xu C, Sin S, McDonough JM, Guez A, Arens R, “Modeling the role of Anatomical Restriction of the Upper Airway in Flow Limitation in Children with OSAS,” American Thoracic Society ATS 2006, May 23, San Diego, CA.
Kim CB, Kresh JY, Wootton DM, “Simultaneous Measurement of Platelet Adhesion, Margination, Shear Stress, and Non-Newtonian Profile,” BMES 2006 Annual Fall Meeting, Chicago, IL, October 2006.
Wootton DM, “Dynamic Lumped Parameter Model Of Airway Collapse,” American Thoracic Society, ATS 2007, May 21.
Wootton DM, “Tissue Engineering Education at the Cooper Union,” NSF CMMI Grantees Conference, Knoxville, TN, January 2008.
Zhang Q, Devlin S, Wasko K, Kleinbart R, Wootton D, Lelkes P, Zhou J, “GOALI/Collaborative Research: Design and Manufacturing of Bioactive Surgical Fixation Devices Using Injection Molding of Gradient Cellular Structures,” NSF Engineering Research and Innovation Conference, June 22-25, 2009, Honolulu, Hawaii.
Geisler C, Lelkes P, Wootton D, Fair R, Zhou J, “Material Selection for Electrowetting Micro Array Printing System for Bioactive Tissue Construct Manufacturing,” NSF Engineering Research and Innovation Conference, June 22-25, 2009, Honolulu, Hawaii.
Hyun-Soo Ko, David M. Wootton. “Three-dimensional Finite Element Model of Upper Airway Flow Limitation.” Biomedical Engineering Society Annual Conference, Pittsburgh, PA, Oct 8, 2010.
Steven C. Persak, Sanghun Sin, Raanan Arens, and David M. Wootton. “Computational fluid dynamics modeling of upper airway during tidal breathing using volume-gated MRI in OSAS and control subjects.” 36th Annual Northeast Bioengineering Conference (NEBEC 2010), New York, NY, March 28, 2010.
DM. Wootton, SH. Sin, S. Persak, K. Nandalike, JM McDonough, R. Arens. “Nasal Resistance in Obese Children with and without OSAS.” Abstract #6254. American Thoracic Society 2010 ATS International Conference, New Orleans, LA, May 16, 2010.
S Persak, S. Sin, R Arens, DM Wootton. “Computational Fluid Dynamics Models of the Upper Airway in Obese Children with and without OSAS.” Abstract #7164. American Thoracic Society 2010 ATS International Conference, New Orleans, LA, May 17, 2010.
David M. Wootton, Steven C. Persak, Sanghun Sin, and Raanan Arens. “Application of Computation Fluid Dynamics (CFD) to Study Mechanical Properties of Obstructive Sleep Apnea in Children.” 12th International Symposium on Sleep and Breathing, Barcelona, Spain, April 7, 2011.
S Persak, S. Sin, R Arens, and DM Wootton. “Computational Fluid Dynamics Modeling of Upper Airway During Tidal Breathing Using Volume-Gated MRI in OSAS and Control Subjects.” ASME 2011 Summer Bioengineering Conference, Farmington, PA, June 23, 2011.
Invited Seminars and Workshops:
University of Maryland, Baltimore County, Mechanical Engineering Seminar, Nov 2, 2001.
New Jersey Institute of Technology, Applied Math Colloquium, Feb 7, 2003.
International Workshop on Pulmonary Functional Imaging, University of Pennsylvania, Nov 12-14, 2004.
“Image-based airway fluid and solid mechanics models of pediatric obstructive sleep apnea,” in PG23 – New insights into the pathophysiology and consequences of Obstructive Sleep Apnea, Postgraduate course, American Thoracic Society, San Francisco, CA, May 19, 2007
NHLBI Workshop, Developmental Aspects of the Upper Airway, March 5-6, 2009
“Image-based modeling of the upper airway in Obstructive Sleep Apnea Syndrome,” Courant Institute of Mathematical Sciences Biomath/COB Colloquium, NYU, Sept 27, 2011.
Panel on Biofluid Mechanics Education, R Banerjee moderator, Session TBMT-4, ASME ICEME 2002, Nov 20, New Orleans, LA.
- Arens R (PI), Wootton DM, “Pathophysiology of OSAS in Obese Children 8 – 17 Years Old,” National Institutes of Health, $360,500 (subcontract to Cooper Union), April 2008 – March 2013.
- Zhou GJ, Yao DG, Lelkes PI, Wootton DM, “GOALI/Collaborative Research: Design and Manufacturing of Bioactive Surgical Fixation Devices Using Injection Molding of Gradient Cellular Structures.” National Science Foundation, Grant CMMI-0800743, $49,925 (to Cooper Union). May 2008 – April 2011.
- Papazoglou E, Wootton D, Lowman A, Lelkes PI, McEachron D, “Smart Biomaterials for Tissue and Regenerative Engineering,” National Science Foundation, $20,500 (subcontract to Cooper Union), July 2009 – June 2011.
- Wootton, DM (PI), Delegrammatikas G. “MRI-R2: Acquisition of Endoscopic Particle Image Velocimetry System and Multiprocessor Computer for Fluid Mechanics Research,” National Science Foundation, $152,857 total, February 2010 – December 2011.
- Arens, R (PI), Udupa JY (PI), Wootton DM (PI), “A Structural & Functional Study of the Upper Airway in Adolescent Girls with PCOS,” National Institutes of Health, Grant 1 R01 HL105212-01, $891,684 (total to Cooper Union), Sept 2010 – Sept 2014.
- Wootton, DM (PI), Ahmed, Z. “Model of Dialysis Access Flow and Thrombosis.” Drexel University Synergy Grant, $20,000, June 2002 – June 2003.
- Wootton, DM (PI). “Platelet-vWF transient binding in shear flow: assay and mechanical model.” American Heart Association, Pennsylvania-Delaware Local Affiliate, $100,000 total, July 2003 – Jun 2005 (extended to Jan 2006).
- Zhou, GJ (PI), Lelkes, PI, Wootton, DM, “Biomimetic Structured Porogen Freeform Fabrication System for Tissue Engineering.” National Science Foundation, $388,704 total, April 2003 – March 2006.
- Zhou GJ (PI), Fair R, Lelkes PI, Wootton DM, “Collaborative Research: Electrowetting Micro Array Printing System for Bioactive Tissue Construct Manufacturing.” National Science Foundation, Grant CMMI- 0654244, $33,654 (to Cooper Union). April 2007 – March 2010.
Patents, Technology Transfer, and Entrepreneurial Activities:
- Ku DN, Greer-Braddon L, Wootton DM, "Poly (Vinyl Alcohol) Cryogel", US Patent #5981826, issued Nov 9, 1999.
- Lec RM, Kresh JY, Wootton DM, “Acoustic Blood Analyzer for Assessing Blood Properties, US Patent # 7,857,761, issued Dec 28, 2010.
Novel Electromechanical Hemostatic Biosensors
In collaboration with Ryszard Lec (Drexel Biomedical Engineering) and Yasha Kresh (Drexel University College of Medicine), Dr. Wootton has developed new sensors to detect hemostatic function based on the propagation and attenuation of shear acoustic waves into cells and proteins that attach to bioactive sensor coatings.
The first-generation sensor is designed as a blood clotting timer, capable of enhancing the function of disposable blood clotting assays for home testing and point-of-care testing. Blood clotting timers are crucial for maintaining the health of patients with artificial heart valves and blood pumps (estimated at 50,000 to 100,000 patients annually), and with improvements in cost and accuracy will enable treatment of a larger class of patients at risk from atrial fibrillation and deep vein thrombosis. An option to license the technology from Drexel University has been granted to SonoMedix, a startup funded by BioAdvance greenhouse funding.
Cryogel Biomaterials for Surgical Applications – Georgia Tech/GTRA/Salumedica
Dr. Wootton is a coinventor of a novel cryogel biomaterial manufacturing process, with Dr. David Ku and Linda Greer Braddon at Georgia Institute of Technology. The invention led to a patent (owned by Georgia Tech), technology seed funding through the Georgia Tech Research Alliance (GTRA), and the formation of a spin-off company, Salumedica, to develop the material for clinical use. Salumedica has an FDA-approved nerve cuff in clinical use, and is completing clinical trials for its second product, an orthopedic implant.